Feasibility of precision smoking treatment in a low-income community setting: results of a pilot randomized controlled trial in The Southern Community Cohort Study

Table 2 Rates of study enrollment, engagement, and retention, overall and by treatment arm

Eligible N = 92	Enrolled/Randomized	Engaged		Retained
	Enrolled/Randomized	All	Received Med	Retained
	(1)	(2a)	(2b)	(3)
Full sample (N)	67	58	43	43
Marginal rate (% of prior stage)	72.8 [63.0, 80.9]	86.6 [76.4, 92.8]	64.2 [52.2, 74.6]	74.1 [61.6, 83.7]
Cumulative rate (% of eligible)	72.8 [63.0, 80.9]	63.0 [52.8, 72.2]	46.7 [36.9, 56.9]	46.7 [36.9, 56.9]
MIC arm only (N)	23	19	11	14
Marginal rate (% of prior stage)		82.6 [62.9, 93.0]	47.8 [29.2, 67.0]	73.7 [51.2, 88.2]
Odds ratio (MIC vs. GBC)		0.75 [0.15, 3.86]	0.34 [0.10, 1.20]	0.33 [0.05, 2.00]
PRS arm only (N)	22	20	16	12
Marginal rate (% of prior stage)		90.9 [72.2, 97.5]	72.7 [51.8, 86.8]	60.0 [38.7, 78.1]
Odds ratio (PRS vs. GBC)		1.58 [0.23, 10.67]	1.00 [0.26, 3.81]	0.18* [0.03, 1.00]

The top panel (“Full Sample”) reports marginal and cumulative rates for each stage of study implementation, where “marginal” denotes rates as a proportion of the prior stage. The middle (“MIC arm only”) and bottom (“PRS arm only”) panels show treatment arm-specific marginal rates as well as results of a logistic regression of each stage (column header) on dummy variables for each of the two precision treatment arms (reference group: Guideline-Based Care arm). “Engaged” refers to completion of the intervention counseling call; Column 2a comprises all participants who completed the intervention call, whereas Column 2b comprises all participants who both completed the intervention call and reported receiving their chosen smoking cessation medication during the study. “Retained” refers to completion of the 6-month follow-up survey
MIC Metabolism-Informed Care, PRS Polygenic Risk Score
^*Significant at the 5% level

ISSN: 1940-0640