- The size of the circles is proportional to the number of systematic reviews (larger = 3 or more; medium = 2; small = 1). Green circle: high methodological quality systematic review; yellow circle: moderate methodological quality systematic review; red circle: critically low or low methodological quality systematic review
- HCV: hepatitis C; HIV: human immunodeficiency virus; NSEP: needle and syringe exchange program; OAT: opioid agonist maintenance treatment; SCF: supervised drug consumption facilities; SIF: supervised injection facility; THN: take-home naloxone program
- *Outcomes:
- HIV incidence/transmission: refers to rates or reported data on infection incidence and transmission
- HIV prevalence: refers to disease prevalence in the population
- HCV incidence / transmission: refers to rates or reported data on infection incidence and transmission
- HCV prevalence: refers to disease prevalence in the population
- Overall risky behavior: refers to any kind of harmful behavior, including sexual risk behavior and related outcomes, injecting behavior or drug use
- Illicit opioid use: refers to the injection of opioid
- Injecting behavior: refers to all of those related to injection practices as reusing or sharing syringes/needles, injecting outdoors [public drug use], rushing injections
- Injection drug use: refers specifically to the use of drugs through injections (i.e., practice, behavior of injecting drugs)
- Sharing needles/syringes: refers specifically to the practice of sharing paraphernalia
- Drug treatment entry: rates of individuals initiating treatment
- Overdose: rates of overdose related to injecting drug behavior
- Deaths: rates of death related to injecting drug behavior