Addiction Science & Clinical Practice

Table 2 Minimum sample size for sensitivity in screening studies, with power > 0.80, α = 0.05, and H₀ = 0.50

From: The Spanish language version of the TAPS tool: protocol for a validation and implementation study in primary care

Prevalence	H₁	N_positive	N_Total
2.5%	0.70	49	1960
2.5%	0.80	20	800
5%	0.70	49	980
5%	0.80	20	400
10%	0.70	49	490
10%	0.80	20	200
20%	0.70	49	245
20%	0.80	20	100

The bolded value of 980 formed the basis for our sample size determination, assuming 5% prevalence and H₁ = 0.70. N = 1000 was chosen to slightly exceed this target in anticipation of missing data
H₀ is assumed to be 0.50, as recommended for screening studies. Adapted from: Bujang, MA & Adnan, TH.⁵⁶

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ISSN: 1940-0640

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