Promoting alcohol treatment engagement post-hospitalization with brief intervention, medications and CBT4CBT: protocol for a randomized clinical trial in a diverse patient population

Edelman, E. Jennifer; Rojas-Perez, Oscar F.; Nich, Charla; Corvino, Joanne; Frankforter, Tami; Gordon, Derrick; Jordan, Ayana; Paris, Jr, Manuel; Weimer, Melissa B.; Yates, Brian T.; Williams, Emily C.; Kiluk, Brian D.

doi:10.1186/s13722-023-00407-9

Addiction Science & Clinical Practice

Table 2 Project ENHANCE: summary of assessments, rationale, and schedule

From: Promoting alcohol treatment engagement post-hospitalization with brief intervention, medications and CBT4CBT: protocol for a randomized clinical trial in a diverse patient population

Domain/Instrument	Rationale	Time point
Domain/Instrument	Rationale	Baseline	34 day follow-up	90 day follow-up
General measures, health status and other key characteristics
Demographic characteristics (e.g., race, ethnicity, primary language of choice)	Description, moderators	X
Hospitalization information (i.e., reason for and days of hospitalization)	Description, moderator	X
General life, economic, housing, and criminal justice status	Description, moderators	X
Usual source of medical care	Description, moderator	X
Technology access and comfort	Description, moderator	X
Cognitive function (Montreal Cognitive Assessment [MoCA]) [103]	Description, moderator	X		X
Self-reported medical comorbidities [104]	Description	X
Medication adherence [105,106,107]	Moderator	X^a
Post-traumatic stress disorder	Description, moderator	X
Patient reported outcomes (PROMIS-Preference [PROPr]) [108]	Moderators, Health utility score	X^a	X^a	X^a
Project ENHANCE Informed consent quiz	Description	X^a
Alcohol-related measures
Alcohol use history (lifetime, past 30 days)	Description, moderator	X
AUDIT-C [43]	Description, moderator	X
Alcohol symptom checklist [46]	Description, moderator	X		X
Alcohol timeline followback [109]	Secondary outcome	X	X	X
Formal alcohol treatment [110] and MAUD adherence [55]	Primary outcome	X	X^b	X^b
Phosphatidylethanol (PEth) [111]	Secondary outcome	X	X	X
Perspectives on treatment for alcohol use disorder [112, 113]	Description, moderator	X
Alcohol readiness ruler	Description, moderator	X^a	X^b	X^b
Alcohol abstinence self-efficacy scale [114]	Mediator	X^a	X^a	X^a
Short Inventory of problems-revised [115]	Secondary outcome	X^a		X^a
Other substance use-related measures
Drug use, past 30 days and age of first use	Moderators	X
Opioid use disorder symptoms [116]	Moderator	X
Severity of drug use problems (ASSIST Lite) [117]	Moderator	X		X
Drug timeline followback	Moderator	X	X	X
Substance use treatment history	Description	X
Family history	Moderator	X
Additional social determinants of health
Health disparities and safety screening tool, adapted [118, 119]	Moderators	X^a
Medical mistrust and discrimination assessment [120]	Moderator	X^a
Everyday discrimination scale [121]	Moderator	X^a
Perceived racial discrimination-adapted	Moderator	X^a
Immigration policy enforcement and related stress [122, 123]	Moderator	X^a
Multidimensional acculturative stress inventory for adults of Mexican origin [124]	Moderator	X^a
Multigroup ethnic identity measure-revised [125]	Moderator	X^a
Treatment services and adverse events
Program and client costs (PACC-SAT) [126,127,128]	Treatment utilization and cost, mediator	X	X
Adverse events (SAFTEE) [129]	Safety outcome		X	X
Process measures
Project EHNANCE session completion, duration	Process	BNI and telephone booster
Yale adherence and competence rating scale, adapted [130]	Intervention fidelity	BNI sessions only
Implementation-related measures
Cost-related data	Cost effectiveness	X	X	X
Participant satisfaction	Evaluation		X^a	X^a,c

^aIndicates participant self-administered via survey
^bVerified with objective measures at follow-up for outcome ascertainment [55, 131]
^cCompleted at 90 day assessment only if not completed at 34 day assessment

Back to article page

ISSN: 1940-0640

Contact us

Submission enquiries: mageshwari.subramani@springernature.com
General enquiries: info@biomedcentral.com