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Table 1 LINC-II eligibility criteria

From: Design of a randomized controlled trial to Link Infectious and Narcology Care (LINC-II) in St. Petersburg, Russia

Inclusion criteria

Exclusion criteria

Age 18 years or older

Not fluent in Russian

HIV-positive

Cognitive impairment precluding informed consent

Hospitalized at narcology hospital

Breastfeeding or being pregnant

History of injection drug use

ART use in the past 30 days prior to hospitalization

Provision of two contacts to assist with follow-up

Acute severe psychiatric illness (i.e., answered yes to any of the following: past three month active hallucinations; mental health symptoms prompting a visit to the emergency room or hospital; mental health medication changes due to worsening symptoms; presence of suicidal ideations)

Address within St. Petersburg or districts within 100 km of St. Petersburg

Known history of liver failure

Possession of a home or mobile phone

Known hypersensitivity to naltrexone

Ability and willingness to comply with all study protocols and procedures

Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) greater than 5 times the upper limit of normal

Severe thrombocytopenia

Known coagulation disorder/taking anticoagulation medications

Body habitus that precludes intramuscular injection (e.g., BMI < 17 or > 45)

Known history of Raynaud’s disease, Itsenko-Cushing syndrome, generalized mycoses, glaucoma, or osteoporosis

Planned surgeries in the next 12 months